Understanding how cell signals change in cancer and heart disease
Official title: Redox regulation of protein kinase function: biochemical mechanisms and cellular consequences
Funded at North Carolina Agri & Tech St Univ · NIH-11144265 · Data updated 2026-11-12
This work explores how changes in cell signals, particularly those affected by oxygen, contribute to diseases like cancer and cardiovascular conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina Agri & Tech St Univ NIH-funded |
| Lab location | 1 site (Greensboro, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $362,500 |
| NIH project number | 5R35GM153737-02 |
| Project ID | NIH-11144265 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research does not directly involve patients, but future clinical applications would target individuals with specific types of cancer or cardiovascular conditions linked to these cellular signaling pathways.
✕Less likely to help
Patients without conditions related to the specific cellular signaling pathways being studied would not directly benefit from this particular research.
What this research studies
Our bodies rely on complex signaling networks within cells to stay healthy, and when these networks go awry, it can lead to serious illnesses. This project focuses on how certain proteins, called protein kinases, are regulated by a process involving reactive oxygen species, which are natural chemicals in our cells. We want to understand how these oxygen-related changes affect the activity and location of these kinases, as this could be a key factor in the development of diseases. By uncovering these basic mechanisms, we hope to find new ways to target these processes for future treatments.
Why it matters
Potential benefit: If successful, this basic science could lead to a deeper understanding of disease mechanisms, potentially paving the way for new drug targets or therapies for cancer and cardiovascular diseases.
How similar studies have gone: Other studies have shown that protein kinases can be regulated by oxidation, suggesting this is a promising area for further investigation.
Where this research is happening
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North Carolina Agri & Tech St Univ
Greensboro, United States Active
Researchers
- Principal investigator: Newman, Robert Howard — North Carolina Agri & Tech St Univ
- Study coordinator: Newman, Robert Howard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.