Understanding how cell signals affect movement and structure in cells
Signal Integration from Membranes to the Actin Cytoskeleton
This study is looking at how certain proteins help control the structure of cells, which is important for things like how cells move and respond to the immune system, and it aims to understand how changes in these proteins can lead to diseases like cancer and immune disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project ID | NIH-10860937 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which actin cytoskeleton regulation influences critical cellular processes such as cell migration, immune responses, and neuron development. The focus is on the Wiskott-Aldrich Syndrome Protein (WASP) family, which connects signals from cell membranes to the actin polymerization process. By utilizing advanced techniques like cryo-electron microscopy, the research aims to uncover how mutations in these proteins contribute to various diseases, including cancers and immune disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic mutations affecting WASP proteins or related conditions, such as immune syndromes or specific cancers.
Not a fit: Patients without genetic mutations in WASP proteins or those not affected by related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to actin regulation, such as certain cancers and immune disorders.
How similar studies have performed: Previous research has shown promising results in understanding actin regulation and its implications in various diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Ames, United States
- Iowa State University — Ames, United States (Active)
Researchers
- Principal investigator: Chen, Baoyu — Iowa State University
- Study coordinator: Chen, Baoyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.