Understanding how cell signaling proteins interact to improve drug design
Official title: Structural Basis and Molecular Mechanism of GPCR-Arrestin Interactions
Funded at Indiana University Indianapolis · NIH-10892255 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells work together to send signals, which could help scientists create better and safer medications for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $396,250 |
| NIH project number | 5R35GM151033-02 |
| Project ID | NIH-10892255 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions influenced by GPCR signaling, such as cardiovascular diseases or hormonal disorders.
✕Less likely to help
Patients with conditions unrelated to GPCR signaling may not receive any benefit from this research.
What this research studies
This research investigates the interactions between G protein-coupled receptors (GPCRs) and arrestins, which are crucial for transmitting signals within cells. By using advanced techniques like cryo-electron microscopy, the researchers aim to visualize these interactions at a near-atomic level. The goal is to uncover the structural details of GPCR-arrestin complexes, which could lead to the development of more effective and safer drugs targeting these pathways. Patients may benefit from new treatments designed based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and safer drugs for various conditions related to GPCR signaling.
How similar studies have gone: Other research has shown success in understanding GPCR interactions, but the specific focus on GPCR-arrestin complexes is relatively novel.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Chen, Qiuyan — Indiana University Indianapolis
- Study coordinator: Chen, Qiuyan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.