Understanding how cell signaling networks affect cancer and cell movement
Deciphering the network structure of signaling dynamics
This study is looking at how certain signals in cancer cells help them move and survive, which could lead to new ways to treat cancer and help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10813163 on NIH RePORTER |
What this research studies
This research investigates the complex signaling network involving Ras GTPases and their effects on cellular processes such as migration and survival, which are crucial in cancer development. By using advanced fluorescent live cell imaging techniques, the study aims to systematically analyze how perturbations in this signaling network influence its dynamics. Patients may benefit from insights gained about how cancer cells move and proliferate, potentially leading to new therapeutic strategies. The research focuses on understanding the underlying mechanisms that could be targeted for improved cancer treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers that exhibit abnormal cell signaling and migration patterns.
Not a fit: Patients with non-malignant conditions or those whose cancers do not involve the Ras signaling network may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers by targeting the signaling pathways that control cell movement and growth.
How similar studies have performed: Previous research has shown promising results in understanding cell signaling dynamics, indicating that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Huang, Chuan-Hsiang — Johns Hopkins University
- Study coordinator: Huang, Chuan-Hsiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.