Understanding how cell signaling maintains healthy tissues
Defining signaling networks in epithelial homeostasis
This study is looking at how certain proteins help control how cells behave and keep our tissues healthy, which could lead to better treatments for diseases that upset this balance.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10894878 on NIH RePORTER |
What this research studies
This research investigates the signaling networks that control cell fate and maintain the balance of epithelial tissues in the body. By focusing on protein kinases, which are crucial for tissue function, the research aims to uncover how these signals influence cell behavior and tissue renewal. The approach involves studying these processes at the single-cell level to identify how different signals can lead to various cell outcomes, which is essential for developing targeted therapies for diseases that disrupt tissue homeostasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that disrupt epithelial tissue homeostasis, such as certain cancers or chronic inflammatory diseases.
Not a fit: Patients with conditions unrelated to epithelial tissue function or those who do not have any epithelial tissue disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases that affect tissue maintenance and regeneration.
How similar studies have performed: Previous research has shown success in understanding signaling pathways in other contexts, suggesting that this approach could yield valuable insights into epithelial homeostasis.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Thorne, Curtis Andrew — University of Arizona
- Study coordinator: Thorne, Curtis Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.