Understanding how cell signaling affects the development of different cell types
Dissecting the role of Erk signaling dynamics in positioning and coordinating germ layer fates
This study is looking at how a specific signaling pathway in our cells helps shape different cell types during early human development, which could lead to new treatments for developmental disorders that some patients may experience.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Barbara NIH-funded |
| Lab location | 1 site (Santa Barbara, United States) |
| Project ID | NIH-10902062 on NIH RePORTER |
What this research studies
This research investigates how the MAPK/Erk signaling pathway influences the development of various cell types during early human development. By using advanced techniques like live cell imaging and optogenetics, researchers aim to understand how dynamic changes in Erk activity can lead to different cell fates. The study will also explore how specific genetic mutations may affect these processes, potentially leading to new therapeutic strategies. Patients may benefit from insights gained into developmental disorders linked to these signaling pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations related to RASopathies or other developmental disorders.
Not a fit: Patients without genetic mutations affecting cell signaling pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for developmental disorders caused by signaling pathway mutations.
How similar studies have performed: Other research has shown promising results using similar optogenetic and CRISPR techniques to manipulate cell signaling pathways.
Where this research is happening
Santa Barbara, United States
- University of California Santa Barbara — Santa Barbara, United States (Active)
Researchers
- Principal investigator: Baxter, Naomi Jessie — University of California Santa Barbara
- Study coordinator: Baxter, Naomi Jessie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.