Understanding how cell signaling affects nerve connections in the ear
Elucidating the Role of Epithelial PCP signaling in SGN Axon Guidance in the Cochlea
This study is looking at how certain signals help important nerve cells in the ear grow and connect properly, which is key for hearing, and it aims to understand what happens when these signals go wrong, potentially leading to hearing problems.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10867397 on NIH RePORTER |
What this research studies
This research investigates the role of Planar Cell Polarity (PCP) signaling in guiding the growth of spiral ganglion neurons (SGNs) in the cochlea, which are crucial for hearing. The study aims to uncover the molecular mechanisms that help these neurons connect to their target hair cells during development. By using advanced techniques, including CRISPR, the researchers will explore how disruptions in this signaling pathway can lead to improper nerve connections, potentially affecting hearing. The findings could provide insights into the biological processes that underlie hearing loss and acoustic trauma.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with hearing loss or those at risk of acoustic trauma.
Not a fit: Patients with hearing loss due to non-neurological causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating hearing loss caused by nerve connection issues.
How similar studies have performed: Previous research has shown promising results in understanding the role of PCP signaling in other developmental processes, suggesting potential success in this area as well.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Clancy, Shaylyn — University of Virginia
- Study coordinator: Clancy, Shaylyn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.