Understanding how cell signaling affects heart development in Down syndrome
Mechanisms for cell signaling in the control of cardiomyogenesis
This study is looking into how certain signals in the body affect heart development in people with Down syndrome, especially to understand why they often have heart defects, and it aims to find ways to improve heart health for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10914374 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind heart development in individuals with Down syndrome, particularly focusing on how increased interferon signaling impacts the Wnt/β-Catenin pathway, which is crucial for cardiogenesis. By utilizing human induced pluripotent stem cells and a mouse model, the study aims to identify the molecular processes that lead to congenital heart defects commonly seen in Down syndrome. The researchers will explore how these signaling pathways can be normalized to improve heart development outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down syndrome, particularly those who have congenital heart defects.
Not a fit: Patients without Down syndrome or those who do not have congenital heart defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve heart health in individuals with Down syndrome.
How similar studies have performed: Previous research has shown promising results in understanding cell signaling pathways related to heart development, indicating potential for success in this area.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Song, Kunhua — University of South Florida
- Study coordinator: Song, Kunhua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.