Understanding how cell signaling affects bone growth in zebrafish fins.
Official title: Sonic hedgehog signaling and skeletal patterning during zebrafish fin regeneration
Funded at University of Oregon · NIH-11125745 · Data updated 2026-11-12
This study is looking at how a special signaling process helps zebrafish regrow their fins, which could teach us more about how bones heal and regenerate in people.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project start | June 16, 2024 |
| Project end | May 15, 2027 |
| Funding year | 2025 |
| Award (this year) | $49,538 |
| NIH project number | 5F31HD113401-02 |
| Project ID | NIH-11125745 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with bone fractures or conditions that impair bone healing.
✕Less likely to help
Patients with non-skeletal conditions or those who do not have issues related to bone growth or repair may not benefit from this research.
What this research studies
This research investigates the role of Sonic hedgehog signaling in the regeneration of zebrafish fins, focusing on how cell signaling influences the interactions between different cell types involved in bone growth. By studying zebrafish, which can regenerate their fins, researchers aim to uncover the genetic and cellular mechanisms that facilitate this process. The project employs advanced imaging techniques to observe these interactions in real-time, providing insights into the cellular behaviors that contribute to skeletal patterning. The findings could have implications for understanding bone repair and regeneration in humans.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing bone healing and regeneration in patients with skeletal injuries or conditions.
How similar studies have gone: Previous research has shown promising results in understanding bone regeneration through similar cellular signaling pathways, indicating that this approach has potential for success.
Where this research is happening
-
University of Oregon
Eugene, United States Active
Researchers
- Principal investigator: Horst, Samuel G — University of Oregon
- Study coordinator: Horst, Samuel G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.