Understanding how cell receptors communicate signals across membranes
Structures and mechanisms of transmembrane receptors
This study is looking at how certain proteins on cell surfaces help cells talk to each other and their surroundings, with the hope of finding new treatments for diseases like cancer and brain disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11010389 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which transmembrane receptors facilitate communication between cells and their environment. By focusing on the structural characteristics of these receptors, particularly single-pass transmembrane receptors, the research aims to uncover how signals are transmitted across cell membranes. The team employs advanced techniques such as cryo-electron microscopy and X-ray crystallography, alongside biochemical and biophysical analyses, to study these receptors in detail. The ultimate goal is to develop targeted therapies for diseases linked to receptor malfunction, such as cancer and neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with conditions related to malfunctioning transmembrane receptors, such as cancer or neurological disorders.
Not a fit: Patients with conditions unrelated to transmembrane receptor signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for various diseases, improving treatment options for patients.
How similar studies have performed: Previous research has shown success in understanding receptor mechanisms, indicating potential for breakthroughs in targeted therapies.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Zhang, Xuewu — Ut Southwestern Medical Center
- Study coordinator: Zhang, Xuewu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.