Understanding how cell powerhouses affect male fertility
Mitochondrial dynamics in spermatogonial differentiation
This research explores how tiny powerhouses inside cells, called mitochondria, work in the cells that create sperm, aiming to understand causes of male infertility.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11158885 on NIH RePORTER |
What this research studies
Our bodies' cells contain mitochondria, which are like tiny engines that produce energy and play many roles beyond just metabolism. These mitochondria constantly change their shape and connections, a process called mitochondrial dynamics, which is crucial for how cells develop and specialize. We are looking at how these changes in mitochondria affect the development of sperm-producing cells, called spermatogonia. Specifically, we want to understand how these cells balance the need for increased energy during sperm development with the potential damage from byproducts of that energy production, which could impact fertility.
Who could benefit from this research
Good fit: This foundational research is relevant for adult men experiencing infertility or those interested in the biological processes behind male reproductive health.
Not a fit: Patients not experiencing male infertility or those seeking immediate clinical treatments would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the fundamental causes of male infertility and potentially new ways to help individuals who cannot achieve a pregnancy.
How similar studies have performed: Our pilot data suggest that mitochondrial fusion and fission are important in spermatogonial differentiation, building on existing knowledge that mitochondria are key players in cell processes.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Wang, Yuan — Michigan State University
- Study coordinator: Wang, Yuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.