Understanding how cell polarity changes contribute to Alzheimer's disease
Official title: Polarity dysregulation in Alzheimer’s disease
Funded at Rutgers Biomedical and Health Sciences · NIH-10999788 · Data updated 2026-11-12
This study is looking at how aging affects brain cells in people with Alzheimer's disease, specifically focusing on a protein called Par3 that might play a role in the disease, to help find new ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,671,360 |
| NIH project number | 1RF1NS130881-01A1 |
| Project ID | NIH-10999788 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those who are middle-aged or older.
✕Less likely to help
Patients with early-onset Alzheimer's disease or those with genetic forms of dementia may not benefit from this research.
What this research studies
This research investigates the relationship between aging and cell polarity in the context of Alzheimer's disease (AD). It focuses on how dysregulation of cellular polarity may lead to the development of AD by examining the role of a specific protein, Par3, which has been linked to increased risk for the disease. The study will utilize advanced genetic and cellular techniques to explore how changes in Par3 expression affect neuronal function and contribute to the pathology of AD. By understanding these mechanisms, the research aims to identify potential targets for therapeutic intervention.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting the underlying mechanisms of cell polarity dysregulation.
How similar studies have gone: While the specific approach of targeting cell polarity in Alzheimer's is relatively novel, there have been successful studies exploring related mechanisms in neurodegenerative diseases.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Zhang, Huaye — Rutgers Biomedical and Health Sciences
- Study coordinator: Zhang, Huaye
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.