Understanding how cell polarity affects the spread of HIV
Role of cell polarity regulators in HIV spreading
This study is looking at how a protein called CDC42 helps HIV spread between immune cells, which could lead to new ways to stop the virus from moving from one cell to another, ultimately helping people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10751046 on NIH RePORTER |
What this research studies
This research investigates the role of a specific protein, CDC42, in how HIV spreads between immune cells. By studying the interactions between HIV-infected and non-infected T cells, the research aims to uncover the mechanisms that allow the virus to efficiently transmit from one cell to another. The approach involves examining the cellular structures and processes that facilitate this transmission, particularly focusing on the polarization of the actin cytoskeleton and the formation of cellular extensions. Patients may benefit from insights gained into potential therapeutic targets that could disrupt HIV transmission.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are interested in understanding the mechanisms of viral transmission.
Not a fit: Patients who are not infected with HIV or those who are not actively engaged in HIV treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing the spread of HIV within the body.
How similar studies have performed: Previous research has shown that targeting cellular mechanisms involved in viral transmission can be effective, suggesting that this approach may yield valuable insights.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Gottlinger, Heinrich — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Gottlinger, Heinrich
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.