Understanding how cell metabolism affects cell development and function
Examining how the spatial partitioning of metabolism underlies cell state
This study is looking at how the way cells organize their energy affects their growth and how they work, which could help us understand new ways to treat different diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10902024 on NIH RePORTER |
What this research studies
This research investigates how the spatial organization of metabolism within and between cells influences their development and function. By examining the interactions between different cellular compartments, such as mitochondria and the cytosol, the study aims to uncover the molecular mechanisms that regulate gene expression through epigenetic changes. The approach involves advanced techniques like CRISPR to manipulate and observe these metabolic processes in real-time. Patients may benefit from insights gained about cellular behavior that could inform new treatments for various diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions that involve cellular dysfunction or developmental disorders.
Not a fit: Patients with acute conditions unrelated to cellular metabolism or differentiation may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to cell differentiation and function.
How similar studies have performed: Other research has shown promising results in understanding cellular metabolism and its impact on cell function, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Bailis, Will H. — Children's Hosp of Philadelphia
- Study coordinator: Bailis, Will H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.