Understanding how cell messengers work to create better medicines
Structural Basis and Molecular Mechanism of GPCR-Arrestin Interactions
['FUNDING_OTHER'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11129842
This research explores how important cell messengers called GPCRs interact with other proteins called arrestins, aiming to help design safer and more effective drugs.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11129842 on ClinicalTrials.gov |
What this research studies
Our bodies rely on tiny messengers called G protein coupled receptors (GPCRs) to receive signals from outside cells and pass them along inside. These signals control many bodily functions, from sensing light to regulating blood pressure. This project focuses on how GPCRs interact with specific partners called arrestins, which are crucial for how cells respond to signals and how drugs work. By creating detailed pictures of these interactions, we hope to uncover new ways to develop medications that are more precise and have fewer side effects.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future clinical applications could benefit patients with conditions related to cell signaling and blood pressure regulation.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to the development of new and improved medications for a wide range of conditions that involve GPCR signaling, with better safety profiles.
How similar studies have performed: While GPCR-G protein interactions are well-studied, understanding GPCR-arrestin interactions is a newer area, with this project building on recent advances in structural biology techniques.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, QIUYAN — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: CHEN, QIUYAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.