Understanding How Cell Membranes Fuse
Mechanisms of Membrane Fusion
This project explores the fundamental ways cell membranes combine, a process crucial for many body functions like hormone release and nerve communication.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-11111158 on NIH RePORTER |
What this research studies
Our bodies rely on cell membranes fusing together for essential processes such as cell growth, hormone secretion, and nerve signal transmission. This research uses yeast cells as a model to uncover the basic steps of how membranes merge, because these mechanisms are similar in yeast and humans. We are working to identify the specific proteins and fats that work together to make fusion happen smoothly, without damaging the cell. By understanding these detailed steps, we hope to learn more about how these vital processes occur in human cells.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation, but it is relevant for patients interested in the basic biological processes underlying human health.
Not a fit: Patients seeking immediate clinical treatments or direct participation in a human clinical trial would not find direct benefit from this basic science project.
Why it matters
Potential benefit: Understanding these fundamental mechanisms could lead to new insights into human diseases where cell fusion is disrupted, such as certain infections or neurological conditions.
How similar studies have performed: Previous work by this team has successfully identified key components and mechanisms of membrane fusion using this yeast model system.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Wickner, William Tobey — Dartmouth College
- Study coordinator: Wickner, William Tobey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.