Understanding how cell membranes are organized and function
Coupling of lateral and transverse organization in complex biomembranes
['FUNDING_R01'] · UNIVERSITY OF TENNESSEE KNOXVILLE · NIH-10691341
This study is looking at how the different layers of cell membranes are put together and how that affects how cells work, which could help us understand more about how cells interact with their surroundings and stay organized.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TENNESSEE KNOXVILLE (nih funded) |
| Locations | 1 site (KNOXVILLE, UNITED STATES) |
| Trial ID | NIH-10691341 on ClinicalTrials.gov |
What this research studies
This research investigates the structure and organization of cell membranes, which are crucial for cellular functions. It aims to explore how the unique compositions of different layers of membranes affect their physical properties and behavior. By using advanced techniques like cryogenic electron microscopy and molecular simulations, the study seeks to uncover the biophysical characteristics of asymmetric membranes, which have been poorly understood until now. This could lead to new insights into how cells interact with their environment and maintain their internal organization.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve cellular membrane abnormalities or dysfunctions.
Not a fit: Patients with conditions unrelated to cell membrane structure or function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cell membrane functions, potentially leading to new therapeutic strategies for diseases related to membrane dysfunction.
How similar studies have performed: While the study of cell membranes is a well-established field, the specific approach of integrating lipidomics with advanced imaging and simulations is relatively novel and has shown promise in preliminary research.
Where this research is happening
KNOXVILLE, UNITED STATES
- UNIVERSITY OF TENNESSEE KNOXVILLE — KNOXVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HEBERLE, FREDERICK A — UNIVERSITY OF TENNESSEE KNOXVILLE
- Study coordinator: HEBERLE, FREDERICK A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.