Understanding how cell membrane organization affects signaling
Spatial Organization of Membrane Signaling
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-10872195
This study looks at how the way molecules are organized on the surface of T cells affects how they communicate and respond to signals, which could help us understand and improve treatments for immune-related diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10872195 on ClinicalTrials.gov |
What this research studies
This research investigates how the arrangement of signaling molecules on cell membranes influences the way cells communicate and respond to external signals. By focusing on T cell receptors, the study aims to uncover the mechanisms that regulate the formation of microclusters—small domains on the membrane that are crucial for effective signaling. The research employs advanced techniques to analyze how changes in lipid composition and membrane structure impact T cell activation and function. Patients may benefit from insights gained into immune responses and potential therapeutic targets for related diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with immune system disorders or those undergoing treatments that affect T cell function.
Not a fit: Patients with conditions unrelated to immune signaling or those not affected by T cell function may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for immune-related disorders by enhancing our understanding of T cell signaling.
How similar studies have performed: Other research has shown success in understanding membrane signaling and its implications for immune responses, indicating that this approach is built on established findings.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SU, XIAOLEI — YALE UNIVERSITY
- Study coordinator: SU, XIAOLEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.