Understanding how cell junctions in the skin work
Nanoscale structure and function of desmosomes
This study is looking at tiny structures in skin cells called desmosomes to see how their protein arrangement helps keep skin cells together, which could help us understand and treat skin disorders caused by weak cell connections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11049278 on NIH RePORTER |
What this research studies
This research investigates the structure and function of desmosomes, which are crucial for maintaining the integrity of skin cells. By using advanced microscopy techniques, the study aims to uncover how the arrangement of proteins within desmosomes affects their ability to hold cells together. This could lead to a better understanding of skin disorders that result from faulty cell adhesion, providing insights into potential treatments. The research combines various scientific disciplines to explore these complex cellular structures in both healthy and diseased states.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with inherited skin disorders that cause erosive skin and mucosal phenotypes.
Not a fit: Patients with skin conditions unrelated to desmosome function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for skin disorders associated with desmosome dysfunction.
How similar studies have performed: While the study of desmosomes is ongoing, this specific approach using super-resolution microscopy is innovative and may provide new insights into cell adhesion mechanisms.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Mattheyses, Alexa Lynn — University of Alabama at Birmingham
- Study coordinator: Mattheyses, Alexa Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.