Understanding how cell junctions and polarity proteins work together
Official title: Intercellular junctions and cell polarity
Funded at Northwestern University at Chicago · NIH-10988275 · Data updated 2026-11-12
This study looks at how certain proteins help keep cells in our tissues organized and working properly, which could lead to new insights that help us understand and treat autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $410,192 |
| NIH project number | 5R01GM148571-03 |
| Project ID | NIH-10988275 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune conditions or those interested in the cellular mechanisms underlying epithelial health.
✕Less likely to help
Patients with non-autoimmune conditions or those unrelated to epithelial cell function may not receive direct benefits from this research.
What this research studies
This research investigates the connections between different types of cell junctions and polarity proteins in epithelial cells. It focuses on how these proteins, specifically Scrib and Par3, regulate the positioning of cell-cell junctions, which are crucial for maintaining the structure and function of tissues. By exploring the mechanisms behind these interactions, the research aims to uncover new insights into cellular architecture and its implications for health and disease. Patients may benefit from a better understanding of how disruptions in these processes can lead to various conditions, particularly autoimmune diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating autoimmune diseases by targeting the mechanisms that regulate cell junctions.
How similar studies have gone: Previous research has shown promising results in understanding cell junctions and polarity proteins, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Troyanovsky, Sergey M — Northwestern University at Chicago
- Study coordinator: Troyanovsky, Sergey M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.