Understanding how cell junctions and polarity proteins work together
Intercellular junctions and cell polarity
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10988275
This study looks at how certain proteins help keep cells in our tissues organized and working properly, which could lead to new insights that help us understand and treat autoimmune diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10988275 on ClinicalTrials.gov |
What this research studies
This research investigates the connections between different types of cell junctions and polarity proteins in epithelial cells. It focuses on how these proteins, specifically Scrib and Par3, regulate the positioning of cell-cell junctions, which are crucial for maintaining the structure and function of tissues. By exploring the mechanisms behind these interactions, the research aims to uncover new insights into cellular architecture and its implications for health and disease. Patients may benefit from a better understanding of how disruptions in these processes can lead to various conditions, particularly autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune conditions or those interested in the cellular mechanisms underlying epithelial health.
Not a fit: Patients with non-autoimmune conditions or those unrelated to epithelial cell function may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating autoimmune diseases by targeting the mechanisms that regulate cell junctions.
How similar studies have performed: Previous research has shown promising results in understanding cell junctions and polarity proteins, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TROYANOVSKY, SERGEY M — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: TROYANOVSKY, SERGEY M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.