Understanding how cell interactions affect thoracic aortic diseases
Official title: Dynamic Cell-Matrix Interactions Dictate Thoracic Aortopathy
Funded at Yale University · NIH-11015429 · Data updated 2026-11-12
This study is looking at how cells interact with their surroundings in the aorta, which can help us find better ways to treat serious conditions like aneurysms and dissections, ultimately aiming to improve care for patients dealing with these issues.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 15, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $358,300 |
| NIH project number | 1P01HL169168-01A1 |
| Project ID | NIH-11015429 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with thoracic aortopathy, such as those with aneurysms or aortic dissections.
✕Less likely to help
Patients with thoracic aortic diseases not caused by cell-extracellular matrix interactions may not benefit from this research.
What this research studies
This research investigates the role of cell-extracellular matrix interactions in thoracic aortopathy, which includes conditions like aneurysms and dissections. By collaborating across five leading laboratories, the project aims to uncover new therapeutic targets and improve treatment strategies for these serious conditions. The research will involve comprehensive testing and coordination among various experts to address critical factors contributing to aortic disease. Patients may benefit from advancements in understanding and managing these life-threatening conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the morbidity and mortality associated with thoracic aortic diseases.
How similar studies have gone: Previous research has shown promise in understanding cell-extracellular matrix interactions in other contexts, suggesting potential for success in this novel approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Humphrey, Jay D. — Yale University
- Study coordinator: Humphrey, Jay D.
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Community Health Worker–Led Hypertension Prevention and Control in Nepal
A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.
-
Community health worker-led hypertension prevention and control in Nepal
A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.
-
Adapting a mobile health tool to boost HIV outcomes for older adults with HIV in Ukraine
A mobile health platform called PositiveLinks would be adapted for older adults with HIV in Ukraine to help them stay engaged in care and improve treatment success.
-
Behavioral and neural links between spoken language sounds and written words in young children
This grant studies how young children learn from listening and reading to improve literacy, by looking at how sound patterns transfer to written language.
-
Understanding how autoimmunity causes myasthenia gravis
This project looks at why the immune system attacks the nerve-muscle connection in myasthenia gravis and how different patient groups are affected.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.