Understanding how cell interactions affect thoracic aortic diseases
Dynamic Cell-Matrix Interactions Dictate Thoracic Aortopathy
['FUNDING_P01'] · YALE UNIVERSITY · NIH-11015429
This study is looking at how cells interact with their surroundings in the aorta, which can help us find better ways to treat serious conditions like aneurysms and dissections, ultimately aiming to improve care for patients dealing with these issues.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11015429 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cell-extracellular matrix interactions in thoracic aortopathy, which includes conditions like aneurysms and dissections. By collaborating across five leading laboratories, the project aims to uncover new therapeutic targets and improve treatment strategies for these serious conditions. The research will involve comprehensive testing and coordination among various experts to address critical factors contributing to aortic disease. Patients may benefit from advancements in understanding and managing these life-threatening conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with thoracic aortopathy, such as those with aneurysms or aortic dissections.
Not a fit: Patients with thoracic aortic diseases not caused by cell-extracellular matrix interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the morbidity and mortality associated with thoracic aortic diseases.
How similar studies have performed: Previous research has shown promise in understanding cell-extracellular matrix interactions in other contexts, suggesting potential for success in this novel approach.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUMPHREY, JAY D. — YALE UNIVERSITY
- Study coordinator: HUMPHREY, JAY D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Aortic Diseases, aortic disorder