Understanding how cell interactions affect the stability of fetal membranes during pregnancy
Intercellular interactions define cell migrations and transitions that maintain fetal membrane homeostasis
This study looks at how the cells in the membranes surrounding a baby during pregnancy work together and how things like aging and inflammation can affect them, which might lead to early birth; it's for anyone interested in understanding what keeps these important membranes healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-10796828 on NIH RePORTER |
What this research studies
This research investigates the cellular interactions within fetal membranes that are crucial for maintaining their stability during pregnancy. It focuses on how aging and inflammation can lead to changes in these membranes, potentially resulting in complications such as preterm birth. By examining the cellular-level changes and the processes of cell migration and transition, the study aims to uncover the mechanisms that contribute to membrane integrity and dysfunction. The research employs advanced techniques to analyze the behavior of amnion epithelial and mesenchymal cells in response to stressors affecting the membranes.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals at risk for preterm birth or those experiencing complications related to fetal membrane integrity.
Not a fit: Patients who are not pregnant or those with no history of complications related to fetal membranes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of preterm birth and related complications.
How similar studies have performed: Previous research has indicated that understanding cellular interactions in similar contexts can lead to significant advancements in maternal-fetal medicine.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Menon, Ramkumar — University of Texas Med Br Galveston
- Study coordinator: Menon, Ramkumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.