Understanding how cell identities and tissue structure develop in early embryos
Official title: Integrating cell identities and morphodynamics through extracellular cues
Funded at California Institute of Technology · NIH-10881976 · Data updated 2026-11-12
This study is looking at how the environment around developing embryos helps shape their cells and tissues, which is really important for healthy pregnancies, using cutting-edge imaging and genetic techniques to understand these early stages better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $128,493 |
| NIH project number | 5K99HD111676-02 |
| Project ID | NIH-10881976 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing recurrent early pregnancy loss or those undergoing fertility treatments.
✕Less likely to help
Patients who are not planning to conceive or those with established pregnancies may not benefit from this research.
What this research studies
This research investigates the critical processes involved in early embryogenesis, focusing on how the extracellular matrix (ECM) influences cell identities and tissue architecture. By utilizing advanced technologies such as 4D imaging and single-cell genomics, the research aims to uncover the mechanisms that regulate cell behavior and pattern formation during the early stages of embryo development. The study will explore the role of the embryonic basement membrane in coordinating these processes, which is essential for successful pregnancy outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of early pregnancy loss.
How similar studies have gone: Other research has shown promising results in understanding the role of the extracellular matrix in embryonic development, indicating that this approach has potential for significant insights.
Where this research is happening
-
California Institute of Technology
Pasadena, United States Active
Researchers
- Principal investigator: Chen, Dong-Yuan — California Institute of Technology
- Study coordinator: Chen, Dong-Yuan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.