Understanding how cell growth leads to cell division in skin stem cells
Determining how cell growth triggers cell division in epidermal stem cells
This study is looking at how skin cells grow and divide, especially focusing on a protein called Rb that plays a big role in this process, to better understand what goes wrong in conditions like cancer and hopefully find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11105791 on NIH RePORTER |
What this research studies
This research investigates the fundamental processes that link cell growth to cell division, particularly in epidermal stem cells. By exploring the molecular mechanisms that regulate the concentration of a key protein called Rb, the study aims to uncover how these processes are misregulated in conditions like cancer. The researchers will utilize advanced techniques, including 2-photon microscopy, to observe these dynamics in living cells. This work could provide insights into how cell size influences division and potentially lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to abnormal cell growth or division, such as certain types of cancer.
Not a fit: Patients with stable, non-cancerous conditions or those not experiencing issues with cell growth or division may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cancers related to cell division misregulation.
How similar studies have performed: Previous research has shown success in understanding cell division mechanisms, but this specific approach focusing on Rb dynamics in vivo is relatively novel.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Skotheim, Jan M — Stanford University
- Study coordinator: Skotheim, Jan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.