Understanding how cell growth affects cancer spread
Elucidating the Relationship Between Cell Proliferation and Invasion
This study is looking at how certain cancer drugs can change the way cancer cells grow and spread, using tiny worms to see if stopping cell division makes cancer cells more aggressive, and it hopes to find better ways to combine these drugs with other treatments to help people with cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10888998 on NIH RePORTER |
What this research studies
This research investigates the relationship between cell proliferation and invasion in cancer, particularly focusing on how certain drugs, known as CDK4/6 inhibitors, affect cancer cell behavior. By using a simple model organism, Caenorhabditis elegans, the study aims to explore how blocking cell division can lead to increased invasiveness of cancer cells. The researchers will analyze the molecular mechanisms involved in this process and evaluate the potential benefits of combining CDK4/6 inhibitors with other treatments to improve cancer therapy outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with metastatic breast cancer who are being treated with CDK4/6 inhibitors.
Not a fit: Patients with non-cancerous conditions or those not receiving CDK4/6 inhibitors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that minimize invasiveness while controlling cell growth.
How similar studies have performed: Other research has shown promising results with CDK4/6 inhibitors in cancer treatment, but the specific relationship between cell cycle arrest and invasiveness is still being explored.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Martinez, Michael Adrian — State University New York Stony Brook
- Study coordinator: Martinez, Michael Adrian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.