Understanding how cell-free hemoglobin affects lung transplant outcomes
Peri-operative factors that drive cell-free hemoglobin-mediated primary graft dysfunction
This study is looking at how a substance called cell-free hemoglobin might lead to problems with lung transplants, and it aims to find ways to help improve the care of patients getting lung transplants by understanding what causes these issues.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10894657 on NIH RePORTER |
What this research studies
This research investigates the role of cell-free hemoglobin (CFH) in causing primary graft dysfunction (PGD) in lung transplant recipients. It aims to understand how both donor and recipient factors, along with surgical management, contribute to the risk of PGD. By studying the cellular mechanisms involved, the research seeks to identify specific therapies that could reduce the risk of PGD. Patients may benefit from insights that could lead to improved management strategies during and after lung transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are undergoing lung transplantation and may be at risk for primary graft dysfunction.
Not a fit: Patients who are not candidates for lung transplantation or those with pre-existing severe lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of primary graft dysfunction in lung transplant patients.
How similar studies have performed: Previous studies have indicated that understanding the role of cell-free hemoglobin in lung injury is a promising area of research, suggesting potential for success in this approach.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Shaver, Ciara M — Vanderbilt University Medical Center
- Study coordinator: Shaver, Ciara M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.