Understanding how cell-free hemoglobin affects kidney health in sickle cell disease
Pathways of Cell-Free Hemoglobin in Sickle Cell Nephropathy
This study is looking at how sickle cell disease can lead to kidney problems in adults, especially focusing on how certain proteins in the blood might harm the kidneys, and it aims to find ways to better protect kidney health for those living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10888217 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which chronic kidney disease develops in adults with sickle cell disease (SCD), focusing on the role of cell-free hemoglobin in causing kidney damage. The study aims to identify genetic factors that may increase the risk of acute kidney injury during vaso-occlusive crises and to explore how cell-free hemoglobin disrupts kidney microvascular function. By examining these pathways, the research seeks to develop targeted interventions that could help protect kidney health in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with sickle cell disease who are at risk for chronic kidney disease.
Not a fit: Patients without sickle cell disease or those who do not have kidney-related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or treat kidney damage in patients with sickle cell disease.
How similar studies have performed: Previous research has shown promising results in understanding kidney complications in sickle cell disease, but this specific approach is innovative and aims to fill critical knowledge gaps.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Saraf, Santosh — University of Illinois at Chicago
- Study coordinator: Saraf, Santosh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.