Understanding how cell-free DNA reveals tissue damage after liver transplants
Decoding the Tissue of Origin of Cellular Damage from Cell-free DNA in Liquid Biopsies
This study is looking at how tiny bits of DNA in your blood can help doctors understand and track any damage to your liver after a transplant, which could lead to better care and outcomes for patients like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10646188 on NIH RePORTER |
What this research studies
This research investigates how cell-free DNA (cfDNA) in the bloodstream can provide insights into tissue damage following liver transplants. By analyzing the specific patterns of cfDNA, researchers aim to identify the origins of cellular damage and monitor changes over time. The study focuses on using molecular techniques to differentiate between the host's and donor's immune cells, which can help in managing graft dysfunction and improving patient outcomes. This minimally invasive approach could lead to better diagnostic tools for post-transplant care.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone a liver transplant and are experiencing complications or require monitoring for graft dysfunction.
Not a fit: Patients who have not had a liver transplant or those with other unrelated medical conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and management of liver transplant patients, enhancing their chances of a successful recovery.
How similar studies have performed: Other research has shown promise in using cfDNA for monitoring various conditions, suggesting that this approach could be effective in the context of liver transplants as well.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Barefoot, Megan Evelyn — Georgetown University
- Study coordinator: Barefoot, Megan Evelyn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.