Understanding How Cell Energy Factories Affect Brain Damage After Stroke
Mitochondrial ROS Microdomains and Neuronal Ischemia
This work explores how tiny signals within our cells' powerhouses, called mitochondria, can either protect or harm brain cells after a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11017843 on NIH RePORTER |
What this research studies
Our cells have tiny power generators called mitochondria, which produce signals known as reactive oxygen species (ROS). While too much ROS can cause damage, a controlled amount might actually help cells. This project aims to understand how the exact location, timing, and amount of ROS production in mitochondria determine whether brain cells are protected or damaged during conditions like stroke. By using advanced light-based tools, we can precisely control ROS production to uncover these complex mechanisms. This knowledge is crucial for developing new ways to protect the brain from injury.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals at risk for or recovering from stroke.
Not a fit: Patients not affected by stroke or related brain injuries would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that protect brain cells from damage after a stroke by targeting how mitochondria produce signals.
How similar studies have performed: While the role of ROS in disease is known, this project uses a novel optogenetic approach to precisely control ROS, which is a relatively new and promising technique.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Wojtovich, Andrew Phillip — University of Rochester
- Study coordinator: Wojtovich, Andrew Phillip
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.