Understanding how cell energy affects the body's fight against tuberculosis
One-carbon metabolism and immune cell function in tuberculosis
This project looks at how the body's energy use in immune cells impacts its ability to fight tuberculosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11122251 on NIH RePORTER |
What this research studies
The project explores how immune cells change their energy use when fighting tuberculosis (TB). Researchers have found that a specific energy process, called one-carbon metabolism, is very active in infected cells and lungs. This process helps cells make important building blocks and manage stress. By understanding how this energy pathway works, and specifically how an enzyme called MTHFD2 is involved, we hope to find new ways to help the body fight off TB infection.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to understand the disease mechanisms relevant to adults with tuberculosis.
Not a fit: Patients seeking immediate new treatments would not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to new treatment strategies that target the energy pathways of immune cells to better control tuberculosis.
How similar studies have performed: While the general concept of immunometabolism in TB is being explored, this specific focus on one-carbon metabolism and MTHFD2 represents a novel area of investigation.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Shi, Lanbo — Rutgers Biomedical and Health Sciences
- Study coordinator: Shi, Lanbo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.