Understanding how cell division is controlled to develop new cancer treatments
Core C: Cell Phenotyping and Molecular Imaging Core
This study is looking at how cells get ready to divide, which is important for understanding cancer, and it's using cool new tools to see how certain proteins work together in real-time to help find new treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11046681 on NIH RePORTER |
What this research studies
This research focuses on the mechanisms that regulate the transition of cells from the G1 phase to the S phase of the cell cycle, which is crucial for cell division. By utilizing advanced techniques such as biochemistry, genetics, and mass spectrometry, the researchers aim to uncover how specific proteins interact and control this process. The study employs innovative imaging technologies, including time-lapse single-cell analysis, to observe these interactions in real-time within living cells. This approach will help identify potential targets for new cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers that are influenced by the Cyclin D-Cdk4/6-Rb-E2F pathway.
Not a fit: Patients with cancers unrelated to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel cancer treatments that more effectively control cell division.
How similar studies have performed: Previous research has shown promise in understanding cell cycle regulation, making this approach a continuation of successful methodologies.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Skotheim, Jan M — Stanford University
- Study coordinator: Skotheim, Jan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.