Understanding how cell division errors contribute to cancer
The systems biology of mitotic checkpoint signaling and its relevance to cancer cell biology
This study is looking at how a special safety system in our cells helps make sure that chromosomes are divided correctly during cell division, which is important because mistakes in this process can lead to cancer, and it aims to find out how these errors happen so we can better understand cancer development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10912436 on NIH RePORTER |
What this research studies
This research investigates the Spindle Assembly Checkpoint (SAC), a crucial mechanism that ensures chromosomes are accurately divided during cell division. By studying how this checkpoint is activated and its signaling dynamics, the research aims to uncover how errors in this process can lead to genome instability in cancer cells. The approach combines experimental techniques with mathematical modeling to explore the timing and effectiveness of the signals that prevent premature cell division. This comprehensive analysis could provide insights into the underlying mechanisms of cancer progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers characterized by genomic instability or those at high risk for developing such cancers.
Not a fit: Patients with non-cancerous conditions or those whose cancers do not involve chromosome missegregation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers associated with chromosome missegregation.
How similar studies have performed: Previous research has shown that understanding cell cycle checkpoints can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Joglekar, Ajit — University of Michigan at Ann Arbor
- Study coordinator: Joglekar, Ajit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.