Understanding how cell division affects tissue structure and cancer development
Official title: Cell cycle control of cell polarity and fate in epidermal morphogenesis
Funded at Princeton University · NIH-11010028 · Data updated 2026-11-12
This study is looking at how cells in our body stay organized while they grow and divide, which is important for stopping cancer, and it aims to find out how certain proteins and enzymes help keep this organization in check, so we can learn more about cancer and possibly find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project start | February 16, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $408,521 |
| NIH project number | 5R01AR068320-08 |
| Project ID | NIH-11010028 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers characterized by loss of cell polarity or those at high risk for developing such cancers.
✕Less likely to help
Patients with non-epithelial cancers or those unrelated to cell polarity issues may not benefit from this research.
What this research studies
This research investigates the mechanisms that maintain cell polarity during the growth and division of epithelial tissues, which is crucial for preventing cancer. It focuses on how polarity proteins are redistributed during cell division and how this process is regulated by specific kinases. By using advanced imaging techniques, the study aims to reveal the dynamic changes in cell polarity and their implications for tissue architecture and tumor suppression. Patients may benefit from insights gained about cancer progression and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers by restoring normal cell behavior.
How similar studies have gone: Previous research has shown that understanding cell polarity mechanisms can lead to significant advancements in cancer treatment, indicating a promising avenue for this investigation.
Where this research is happening
-
Princeton University
Princeton, United States Active
Researchers
- Principal investigator: Devenport, Danelle N — Princeton University
- Study coordinator: Devenport, Danelle N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.