Understanding how cell division affects tissue structure and cancer development
Cell cycle control of cell polarity and fate in epidermal morphogenesis
This study is looking at how cells in our body stay organized while they grow and divide, which is important for stopping cancer, and it aims to find out how certain proteins and enzymes help keep this organization in check, so we can learn more about cancer and possibly find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project ID | NIH-11010028 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that maintain cell polarity during the growth and division of epithelial tissues, which is crucial for preventing cancer. It focuses on how polarity proteins are redistributed during cell division and how this process is regulated by specific kinases. By using advanced imaging techniques, the study aims to reveal the dynamic changes in cell polarity and their implications for tissue architecture and tumor suppression. Patients may benefit from insights gained about cancer progression and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers characterized by loss of cell polarity or those at high risk for developing such cancers.
Not a fit: Patients with non-epithelial cancers or those unrelated to cell polarity issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers by restoring normal cell behavior.
How similar studies have performed: Previous research has shown that understanding cell polarity mechanisms can lead to significant advancements in cancer treatment, indicating a promising avenue for this investigation.
Where this research is happening
Princeton, UNITED STATES
- Princeton University — Princeton, United States (Active)
Researchers
- Principal investigator: Devenport, Danelle N — Princeton University
- Study coordinator: Devenport, Danelle N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.