Understanding how cell division affects brain development in autism
Official title: Characterization of midbody remnant mediated cell fate decisions in autism
Funded at University of Wisconsin-Madison · NIH-11039481 · Data updated 2026-11-12
This study is looking at how certain brain cells divide and how this might relate to autism, focusing on tiny structures that could help understand how brain development goes awry in some individuals.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $194,375 |
| NIH project number | 1R21MH138941-01 |
| Project ID | NIH-11039481 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those under 21 years old.
✕Less likely to help
Patients with autism spectrum disorder who are over 21 years old may not benefit directly from this research.
What this research studies
This research investigates how the division of neural progenitor cells (NPCs) contributes to brain development and its implications for autism spectrum disorder (ASD). The study focuses on a novel mechanism involving midbody remnants (MBRs), which are large extracellular vesicles that may play a role in transferring genetic information that influences cell fate decisions. By examining the dynamics of MBRs and their associated mRNAs in the developing human cortex, the research aims to uncover the molecular pathways that may lead to neurodevelopmental alterations in individuals with ASD. This collaborative effort seeks to provide insights into the developmental origins of ASD and how various risk factors may impact brain architecture.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the biological mechanisms underlying autism, potentially informing new therapeutic strategies.
How similar studies have gone: While the specific approach of examining midbody remnants in relation to ASD is novel, previous research has shown success in exploring cellular mechanisms related to neurodevelopmental disorders.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Wolter, Justin — University of Wisconsin-Madison
- Study coordinator: Wolter, Justin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.