Understanding how cell death is regulated in diseases like heart failure
Molecular and Chemical Regulation of Cell Death in Disease
This study is looking at how certain cells in the heart die and how we can stop that from happening, which could help people with heart problems, especially those affected by inflammation or chemotherapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11091211 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind cell death, specifically focusing on apoptosis and necroptosis, which are critical in various diseases including heart failure. By utilizing advanced techniques like CRISPR to identify key proteins involved in these processes, the study aims to develop small molecular inhibitors that could potentially treat conditions related to dysregulated cell death. Patients may benefit from insights gained about how to protect heart cells from damage caused by factors like inflammation and chemotherapy drugs. The research also explores the role of specific proteins in cardiac cell death, which could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients suffering from heart failure or those at risk of cardiac toxicity due to treatments like chemotherapy.
Not a fit: Patients with conditions unrelated to cell death mechanisms or those not experiencing cardiac issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect heart cells from damage and improve outcomes for patients with heart failure.
How similar studies have performed: Previous research has shown promise in targeting cell death pathways for therapeutic benefit, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Wang, Zhigao — University of South Florida
- Study coordinator: Wang, Zhigao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.