Understanding how cell death is regulated in diseases like heart failure
Official title: Molecular and Chemical Regulation of Cell Death in Disease
Funded at University of South Florida · NIH-11091211 · Data updated 2026-11-12
This study is looking at how certain cells in the heart die and how we can stop that from happening, which could help people with heart problems, especially those affected by inflammation or chemotherapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | June 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $412,500 |
| NIH project number | 1R35GM158455-01 |
| Project ID | NIH-11091211 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients suffering from heart failure or those at risk of cardiac toxicity due to treatments like chemotherapy.
✕Less likely to help
Patients with conditions unrelated to cell death mechanisms or those not experiencing cardiac issues may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind cell death, specifically focusing on apoptosis and necroptosis, which are critical in various diseases including heart failure. By utilizing advanced techniques like CRISPR to identify key proteins involved in these processes, the study aims to develop small molecular inhibitors that could potentially treat conditions related to dysregulated cell death. Patients may benefit from insights gained about how to protect heart cells from damage caused by factors like inflammation and chemotherapy drugs. The research also explores the role of specific proteins in cardiac cell death, which could lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect heart cells from damage and improve outcomes for patients with heart failure.
How similar studies have gone: Previous research has shown promise in targeting cell death pathways for therapeutic benefit, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Wang, Zhigao — University of South Florida
- Study coordinator: Wang, Zhigao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.