Understanding how cell death affects inflammation and organ injury
Official title: Cell Death Programs as Fundamental Drivers of Inflammation and Multi-Organ Injury
Funded at Herbert H. Lehman College · NIH-10974816 · Data updated 2026-11-12
This study is looking at how certain cell death processes affect inflammation during bacterial infections, aiming to find ways to boost the good inflammation that helps you heal while reducing the bad inflammation that can cause damage.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Herbert H. Lehman College NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $412,746 |
| NIH project number | 1R15AI185729-01 |
| Project ID | NIH-10974816 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from acute infections that may lead to systemic inflammation and organ injury.
✕Less likely to help
Patients with chronic inflammatory conditions unrelated to acute infections may not benefit from this research.
What this research studies
This research investigates the role of cell death programs in inflammation and how they can lead to either protective or harmful effects on the body during bacterial infections. By examining the mechanisms of cell death, the study aims to differentiate between beneficial inflammation that helps fight infections and harmful inflammation that can cause tissue damage and organ failure. The researchers will focus on specific proteins involved in these processes to develop targeted therapies that can mitigate harmful inflammation while preserving protective responses.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent organ damage caused by excessive inflammation during infections.
How similar studies have gone: Previous research has shown promising results in understanding the role of cell death in inflammation, suggesting that this approach could lead to significant advancements in treatment strategies.
Where this research is happening
-
Herbert H. Lehman College
New York, United States Active
Researchers
- Principal investigator: Mandal, Pratyusha — Herbert H. Lehman College
- Study coordinator: Mandal, Pratyusha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.