Understanding how cell death affects eye diseases caused by cytomegalovirus
Official title: Programmed cell death and cytomegalovirus retinitis pathogenesis
Funded at Georgia State University · NIH-11060055 · Data updated 2026-11-12
This study is looking at how certain types of cell death affect eye damage from cytomegalovirus retinitis in people with AIDS, using mice to help find better ways to diagnose and treat this serious eye condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 30, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $387,704 |
| NIH project number | 5R01EY034120-03 |
| Project ID | NIH-11060055 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with AIDS who are at risk of developing cytomegalovirus retinitis.
✕Less likely to help
Patients who do not have AIDS or cytomegalovirus-related eye diseases may not benefit from this research.
What this research studies
This research investigates the role of programmed cell death in the development of cytomegalovirus retinitis, a serious eye disease associated with AIDS. By using a mouse model that mimics the immunosuppression seen in AIDS patients, the study aims to uncover how different forms of cell death contribute to retinal damage caused by the virus. The researchers will explore mechanisms like apoptosis, necroptosis, and pyroptosis to better understand their impact on the disease's progression. This knowledge could lead to improved strategies for diagnosing and treating this sight-threatening condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent vision loss in patients with cytomegalovirus retinitis.
How similar studies have gone: Other research has shown promise in understanding the role of cell death in viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Georgia State University
Atlanta, United States Active
Researchers
- Principal investigator: Dix, Richard D — Georgia State University
- Study coordinator: Dix, Richard D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.