Understanding how cell death affects breast cancer progression
Mitophagy-Mediated Cell Death in Mammary Tumorigenesis
This study is looking at how breast cancer cells manage to stay alive even when they break away from their usual surroundings, and it hopes to find new ways to help treat the cancer before it spreads to other parts of the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project ID | NIH-10911986 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of cell death in breast cancer, particularly focusing on how cancer cells survive when detached from their surrounding environment. It explores the role of reactive oxygen species (ROS) in cell survival and how cancer cells may evade death despite losing their attachment to the extracellular matrix. By identifying the cellular changes that occur during this process, the research aims to uncover new therapeutic targets to eliminate cancer cells before they can spread to other organs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those at risk of metastasis.
Not a fit: Patients with non-cancerous conditions or those whose breast cancer is already at an advanced metastatic stage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the spread of breast cancer and improve survival rates for patients.
How similar studies have performed: Previous research has shown promise in targeting cell death mechanisms in cancer, suggesting that this approach could yield significant advancements in treatment.
Where this research is happening
Notre Dame, United States
- University of Notre Dame — Notre Dame, United States (Active)
Researchers
- Principal investigator: Schafer, Zachary T. — University of Notre Dame
- Study coordinator: Schafer, Zachary T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.