Understanding how cell death affects breast cancer growth and spread
Mitophagy-Mediated Cell Death in Mammary Tumorigenesis
This study is looking at how breast cancer cells manage to survive when they break away from their usual surroundings, and it aims to find new ways to stop these cells from spreading by understanding the role of certain molecules in their survival and death.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project ID | NIH-11114625 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of cell death in breast cancer, particularly focusing on how cancer cells survive when detached from their normal environment. It explores the role of reactive oxygen species (ROS) in cell survival and death, aiming to identify new therapeutic targets that could prevent cancer cells from spreading. By studying the cellular changes that occur during this process, the research seeks to develop innovative treatments that could eliminate cancer cells before they metastasize.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer, particularly those at risk of metastasis.
Not a fit: Patients with non-cancerous conditions or those whose breast cancer has already metastasized may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively prevent the spread of breast cancer, improving survival rates for patients.
How similar studies have performed: Previous research has shown promise in targeting cell death mechanisms in cancer, indicating that this approach could yield significant advancements.
Where this research is happening
Notre Dame, United States
- University of Notre Dame — Notre Dame, United States (Active)
Researchers
- Principal investigator: Schafer, Zachary T. — University of Notre Dame
- Study coordinator: Schafer, Zachary T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.