Understanding how cell death affects brain function after cancer treatment in children
Developmental regulation of apoptosis as a modifiable driver of radiotherapy-induced neurocognitive impairment in pediatric patients
This study is looking at how radiation therapy affects the brains of kids with brain tumors and how it might cause problems with thinking and learning, so we can find ways to help improve their quality of life after treatment.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10872489 on NIH RePORTER |
What this research studies
This research investigates the effects of radiation therapy on the brain in pediatric patients with central nervous system tumors, particularly focusing on how it leads to neurocognitive impairments. The study aims to understand the biological mechanisms behind these impairments, specifically the role of apoptosis, or programmed cell death, in brain cells. By examining the BCL-2 family of proteins that regulate apoptosis, the research seeks to identify potential strategies to mitigate these negative effects and improve the quality of life for young cancer survivors. Patients may be involved in assessments that help determine the impact of their treatment on cognitive functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients diagnosed with central nervous system tumors who are undergoing or have undergone radiation therapy.
Not a fit: Patients with non-CNS tumors or those who have not received radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that reduce cognitive impairments in children treated for brain tumors, enhancing their long-term quality of life.
How similar studies have performed: Previous research has shown that understanding apoptosis can lead to breakthroughs in mitigating treatment side effects, suggesting potential for success in this area.
Where this research is happening
Boston, United States
- Harvard School of Public Health — Boston, United States (Active)
Researchers
- Principal investigator: Sarosiek, Kristopher Andrew — Harvard School of Public Health
- Study coordinator: Sarosiek, Kristopher Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.