Understanding how cell death affects aging and reproduction
Molecular mechanisms of ferroptosis induction throughout germline development and aging
['FUNDING_OTHER'] · WASHINGTON STATE UNIVERSITY · NIH-11001505
This study looks at how certain foods and iron can cause a specific type of cell death called ferroptosis, especially as we age, using tiny worms to learn more about how this process works and how it might help in treating cancer and other related diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON STATE UNIVERSITY (nih funded) |
| Locations | 1 site (PULLMAN, UNITED STATES) |
| Trial ID | NIH-11001505 on ClinicalTrials.gov |
What this research studies
This research investigates the process of ferroptosis, a type of cell death that is influenced by iron and dietary factors, particularly during aging and germline development. Using the model organism Caenorhabditis elegans, the study aims to uncover how dietary components, such as polyunsaturated fatty acids, can induce ferroptosis in germ cells. The research will explore the underlying mechanisms of this process, including the role of metabolic pathways and cellular organelles. By understanding these mechanisms, the research seeks to identify potential therapeutic strategies for targeting cancerous tumors and other diseases associated with ferroptosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that may be responsive to therapies targeting ferroptosis.
Not a fit: Patients with conditions unrelated to cancer or those not affected by ferroptosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new cancer therapies that harness the process of ferroptosis to selectively kill cancer cells.
How similar studies have performed: While the concept of ferroptosis is relatively new, preliminary studies have shown promise in understanding its role in cancer therapy, indicating potential for success in this area.
Where this research is happening
PULLMAN, UNITED STATES
- WASHINGTON STATE UNIVERSITY — PULLMAN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WATTS, JENNIFER L — WASHINGTON STATE UNIVERSITY
- Study coordinator: WATTS, JENNIFER L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy, Cancer cell line, cancer therapy, Cancer Treatment, cancer-directed therapy