Understanding how cell damage triggers immune responses in the lungs
Cell lysis-induced leukotriene synthesis activates type-2 immunity in the lung
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11044420
This study is looking at how certain immune cells in the lungs react to things like allergens and parasites, and it hopes to find new ways to help people with allergies and asthma by understanding how these immune responses work.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11044420 on ClinicalTrials.gov |
What this research studies
This research investigates how certain immune cells in the lungs respond to allergens and parasitic infections. It focuses on the role of specific signals released when cells are damaged, which activate a type of immune response known as type 2 immunity. By studying the production of leukotrienes and their impact on immune cell function, the research aims to uncover the mechanisms behind allergic reactions and asthma. Patients may benefit from insights that could lead to new treatments for these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from asthma or allergic diseases who may be affected by immune responses to allergens.
Not a fit: Patients with non-allergic respiratory conditions or those not experiencing asthma or allergic reactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for asthma and allergic diseases by targeting the mechanisms that trigger these conditions.
How similar studies have performed: Previous research has shown promising results in understanding immune responses related to allergens, suggesting that this approach may yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VON MOLTKE, JAKOB H. — UNIVERSITY OF WASHINGTON
- Study coordinator: VON MOLTKE, JAKOB H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Allergic Disease