Understanding how cell damage triggers immune responses in the lungs
Official title: Cell lysis-induced leukotriene synthesis activates type-2 immunity in the lung
Funded at University of Washington · NIH-11044420 · Data updated 2026-11-12
This study is looking at how certain immune cells in the lungs react to things like allergens and parasites, and it hopes to find new ways to help people with allergies and asthma by understanding how these immune responses work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | February 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $880,735 |
| NIH project number | 1R01HL172817-01A1 |
| Project ID | NIH-11044420 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from asthma or allergic diseases who may be affected by immune responses to allergens.
✕Less likely to help
Patients with non-allergic respiratory conditions or those not experiencing asthma or allergic reactions may not benefit from this research.
What this research studies
This research investigates how certain immune cells in the lungs respond to allergens and parasitic infections. It focuses on the role of specific signals released when cells are damaged, which activate a type of immune response known as type 2 immunity. By studying the production of leukotrienes and their impact on immune cell function, the research aims to uncover the mechanisms behind allergic reactions and asthma. Patients may benefit from insights that could lead to new treatments for these conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for asthma and allergic diseases by targeting the mechanisms that trigger these conditions.
How similar studies have gone: Previous research has shown promising results in understanding immune responses related to allergens, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Von Moltke, Jakob H. — University of Washington
- Study coordinator: Von Moltke, Jakob H.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.