Understanding how cell damage and inflammation contribute to pancreatitis
Impaired autophagy, mitochondrial dysfunction, and inflammation in pancreatitis
This study is looking into how problems with cell recycling and energy production in the pancreas can cause inflammation and damage, with the goal of finding new ways to treat pancreatitis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11009512 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind pancreatitis, a serious condition affecting the pancreas. It focuses on how impaired autophagy and mitochondrial dysfunction in acinar cells lead to inflammation and cell damage. By studying these processes, the research aims to uncover potential pathways that could be targeted for new treatments. The approach includes experimental models that mimic human disease to better understand the underlying causes of pancreatitis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatitis or those at risk of developing this condition.
Not a fit: Patients with pancreatitis caused by factors unrelated to autophagy or mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that effectively reduce inflammation and improve outcomes for patients with pancreatitis.
How similar studies have performed: Previous studies have shown promising results in understanding the role of autophagy and mitochondrial function in other inflammatory diseases, suggesting potential for success in this area as well.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Gukovsky, Ilya — University of California Los Angeles
- Study coordinator: Gukovsky, Ilya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.