Understanding how cell connections contribute to heart development
Investigating how mechanical connectivity yields developmental robustness
This study looks at how the way cells connect with each other affects how tissues, like the heart, grow and stay healthy, especially when they face challenges, using fruit flies to learn more about these important processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project ID | NIH-11007202 on NIH RePORTER |
What this research studies
This research investigates how mechanical connections between cells influence the development of tissues, particularly in the context of heart formation. By studying the interactions of cells under various conditions, the project aims to uncover how these connections help maintain proper tissue shape and function, even when faced with challenges like damage or environmental changes. The researchers utilize advanced imaging techniques and algorithms to analyze the behavior of cell networks over time, focusing on the Drosophila fruit fly as a model organism. This approach could provide insights into the fundamental processes that ensure robust development in living organisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital heart defects or those interested in the biological mechanisms of heart development.
Not a fit: Patients with fully developed hearts and no history of congenital defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating heart defects by enhancing our understanding of tissue development.
How similar studies have performed: Other research has shown promising results in understanding tissue development through mechanical interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
Waltham, United States
- Brandeis University — Waltham, United States (Active)
Researchers
- Principal investigator: Duclos Yevick, Hannah Gabrielle — Brandeis University
- Study coordinator: Duclos Yevick, Hannah Gabrielle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.