Understanding how cell connections and internal forces keep our tissues healthy
Cell junction and nuclear forces as mediators of epithelial cell homeostasis
This project explores how the connections between cells and forces within them work to maintain healthy body tissues, especially in relation to conditions like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11113935 on NIH RePORTER |
What this research studies
Our bodies are lined with epithelial cells, which form protective layers and structures like tubes and ducts. When these cells don't form or function correctly, it can lead to problems such as poor wound healing, issues with body barriers, and even cancer. This project aims to understand how the strong connections between these cells, called cell junctions, and the forces within the cell's control center, the nucleus, work together to maintain healthy tissues. By learning more about these fundamental processes, we hope to uncover new insights into how diseases like cancer develop.
Who could benefit from this research
Good fit: This is a basic science project and does not directly involve patient participation or recruitment at this stage.
Not a fit: Patients seeking immediate clinical treatments or direct participation in a clinical trial would not find a direct benefit from this foundational research.
Why it matters
Potential benefit: If successful, this foundational work could provide new insights into the basic mechanisms of cancer development and tissue dysfunction, potentially leading to future strategies for prevention or treatment.
How similar studies have performed: While the importance of cell junctions and nuclear forces in cell biology is known, this specific investigation into their combined role in epithelial homeostasis and disease progression represents a novel area of focus.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Conway, Daniel E — Ohio State University
- Study coordinator: Conway, Daniel E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.