Understanding how cell connections affect palate formation
Determining the role of cell-cell adhesions in palate closure
['FUNDING_FELLOWSHIP'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10903205
This study is looking at how certain cells in the mouth work together during pregnancy to help form the palate properly, and it hopes to find ways to help people with cleft palate by understanding what goes wrong in this process.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10903205 on ClinicalTrials.gov |
What this research studies
This research investigates the specific signaling mechanisms in the oral tissues that are crucial for the proper closure of the palate during embryonic development. By focusing on the interactions between different cell types, the study aims to uncover how disruptions in these connections can lead to conditions like cleft palate. The research employs advanced techniques in cell and developmental biology to explore the roles of specific proteins involved in cell adhesion. Insights gained from this work could lead to improved genetic therapies for individuals affected by cleft palate.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of cleft palate or those at risk of developing this condition.
Not a fit: Patients without any craniofacial abnormalities or those not affected by cleft palate may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options and preventive strategies for cleft palate, a common birth defect.
How similar studies have performed: Previous research has shown promising results in understanding cell adhesion mechanisms related to craniofacial development, indicating that this approach has potential for success.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KING, JULIET STANTON — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: KING, JULIET STANTON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.