Understanding how cell competition affects aging and aneuploidy
Official title: Cell competition, aneuploidy, and aging
Funded at Albert Einstein College of Medicine · NIH-10834249 · Data updated 2026-11-12
This study is looking at how certain unhealthy cells in our bodies might affect aging and whether getting rid of them can help us feel better as we get older, especially for those dealing with age-related health issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | May 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $202,849 |
| NIH project number | 5R21AG081846-02 |
| Project ID | NIH-10834249 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those experiencing age-related health issues or diseases associated with cellular senescence.
✕Less likely to help
Patients who are younger than 21 years old or do not have age-related conditions may not benefit from this research.
What this research studies
This research investigates the role of cell competition in aging and the presence of aneuploid cells, which have an abnormal number of chromosomes. It aims to understand how eliminating these damaged cells can improve age-related health issues. By studying the mechanisms of cell competition, particularly in the context of ribosomal protein gene dosage, the research seeks to find ways to reduce the accumulation of senescent cells that contribute to aging. The findings could lead to new strategies for promoting healthier aging.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve health and longevity in older adults by targeting and eliminating harmful senescent cells.
How similar studies have gone: Previous studies have shown promising results in understanding cellular senescence and its impact on aging, suggesting that this approach could yield significant insights.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Huffman, Derek Major — Albert Einstein College of Medicine
- Study coordinator: Huffman, Derek Major
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.