Understanding how cell communication affects tissue development and disease
Decoding cortical Notch signaling and morphogenic instruction at cell-cell interfaces
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11078143
This study is looking at how our genes and the way our cells are arranged work together to help tissues grow and heal, which could help us understand diseases like cancer and heart problems better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11078143 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between genetic programs and the physical organization of cells, focusing on how these processes influence tissue development and regeneration. By examining cell-cell interfaces, the study aims to uncover how signals that affect gene expression and cell mechanics work together to shape multicellular structures. The research utilizes advanced biomimetic microfluidic models to simulate human tissues, allowing for a detailed exploration of the Notch signaling pathway and its role in regulating cell behavior. This approach could lead to new insights into how dysregulation of these processes contributes to diseases such as cancer and cardiovascular disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to tissue development, such as certain cancers or cardiovascular diseases.
Not a fit: Patients with stable, non-progressive conditions unrelated to tissue development or regeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to tissue development and regeneration.
How similar studies have performed: Previous research has shown promise in understanding cell signaling pathways and their impact on tissue behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KUTYS, MATTHEW L — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: KUTYS, MATTHEW L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.