Understanding how cell communication affects tissue development and disease
Official title: Decoding cortical Notch signaling and morphogenic instruction at cell-cell interfaces
Funded at University of California, San Francisco · NIH-11078143 · Data updated 2026-11-12
This study is looking at how our genes and the way our cells are arranged work together to help tissues grow and heal, which could help us understand diseases like cancer and heart problems better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 20, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $60,885 |
| NIH project number | 3R35GM150987-02S1 |
| Project ID | NIH-11078143 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions related to tissue development, such as certain cancers or cardiovascular diseases.
✕Less likely to help
Patients with stable, non-progressive conditions unrelated to tissue development or regeneration may not benefit from this research.
What this research studies
This research investigates the complex interactions between genetic programs and the physical organization of cells, focusing on how these processes influence tissue development and regeneration. By examining cell-cell interfaces, the study aims to uncover how signals that affect gene expression and cell mechanics work together to shape multicellular structures. The research utilizes advanced biomimetic microfluidic models to simulate human tissues, allowing for a detailed exploration of the Notch signaling pathway and its role in regulating cell behavior. This approach could lead to new insights into how dysregulation of these processes contributes to diseases such as cancer and cardiovascular disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to tissue development and regeneration.
How similar studies have gone: Previous research has shown promise in understanding cell signaling pathways and their impact on tissue behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Kutys, Matthew L — University of California, San Francisco
- Study coordinator: Kutys, Matthew L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.