Understanding how cell communication affects obesity-related diseases
Mechanistic Connection between Interorganellar Communication and Obesity-associated Diseases
This study is looking at a protein called CLSTN3B in fat cells to understand how it affects fat storage and could help us find new ways to treat obesity and related health problems like type 2 diabetes and heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11046688 on NIH RePORTER |
What this research studies
This research investigates the role of a specific protein, CLSTN3B, in fat cells and how it influences the body's ability to store fat. By studying mice with different levels of this protein, the researchers aim to uncover the mechanisms that lead to obesity-related conditions like type 2 diabetes and cardiovascular diseases. The study focuses on the interaction between lipid droplets, which store fat, and the endoplasmic reticulum, a cell structure involved in fat metabolism. Patients may benefit from insights that could lead to new treatments for obesity and its associated health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for obesity-related conditions, particularly those with metabolic disorders.
Not a fit: Patients who are not affected by obesity or related metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating obesity-related diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of cellular mechanisms in obesity, suggesting that this approach could yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Zeng, Xing — Ut Southwestern Medical Center
- Study coordinator: Zeng, Xing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.