Understanding how cell changes lead to aggressive leukemia
The role for phase separation in oncogenesis and aberrant chromatin looping formation
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11116919
This project looks into how specific gene changes in cells contribute to aggressive forms of acute myeloid leukemia (AML) in patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11116919 on ClinicalTrials.gov |
What this research studies
We know that certain changes in a gene called NUP98 are common in patients with acute myeloid leukemia (AML) and often lead to poor outcomes. This project explores how these NUP98 gene changes cause cells to form abnormal structures, similar to oil and water separating, which then drives the development of aggressive AML. By understanding this process, we hope to uncover new ways to stop the disease from progressing. This work focuses on how these gene changes affect the way DNA is organized and expressed, leading to cancer growth.
Who could benefit from this research
Good fit: This research is most relevant to patients diagnosed with acute myeloid leukemia, particularly those whose disease involves rearrangements of the NUP98 gene.
Not a fit: Patients with other types of leukemia or those whose AML does not involve NUP98 gene rearrangements may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients with aggressive forms of acute myeloid leukemia, especially those with NUP98 gene rearrangements.
How similar studies have performed: This work builds on the researchers' own preliminary findings, suggesting a novel mechanism for leukemia development that has not been widely explored.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, G GREG — DUKE UNIVERSITY
- Study coordinator: WANG, G GREG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.